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Rethinking Serotonin’s Role in Depression

Benkelfat, C., Ellenbogen, M. A., Dean, P., Palmour, R. M., & Young, S. N. (1994). Mood-Lowering Effect of Tryptophan Depletion: Enhanced Susceptibility in Young Men at Genetic Risk for Major Affective Disorders. Archives of General Psychiatry, 51(9), 687–697. doi:10.1001/archpsyc.1994.03950090019003

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000). Antidepressant effects of ketamine in depressed patients. Biological Psychiatry, 47(4), 351–354.

Cole, C. E., Patterson, R. M., Craig, J. B., Thomas, W. E., Ristine, L. P., Stahly, M., & Pasamanick, B. (1959). A Controlled Study of Efficacy of Iproniazid in Treatment of Depression. A.M.A. Archives of General Psychiatry, 1(5), 513–518. doi:10.1001/archpsyc.1959.03590050081010

deVerteuil, R. L., & Lehmann, H. E. (1958). Therapeutic Trial of Iproniazid (Marsilid) in Depressed and Apathetic Patients. Canadian Medical Association Journal, 78(2), 131–133.

Duman, R. S., & Li, N. (2012). A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1601), 2475–2484. doi:10.1098/rstb.2011.0357

Fangmann, P., Assion, H.-J., Juckel, G., González, C. A., & López-Muñoz, F. (2008). Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part II: tricyclics and tetracyclics. Journal of Clinical Psychopharmacology, 28(1), 1–4. doi:10.1097/jcp.0b013e3181627b60

Feighner, J. P., Boyer, W. F., Merideth, C. H., & Hendrickson, G. G. (1989). A double-blind comparison of fluoxetine, imipramine and placebo in outpatients with major depression. International Clinical Psychopharmacology, 4(2), 127–134.

Freis, E. D. (1954). Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine. New England Journal of Medicine, 251(25), 1006–1008. doi:10.1056/NEJM195412162512504

Hillhouse, T. M., & Porter, J. H. (2015). A brief history of the development of antidepressant drugs: From monoamines to glutamate. Experimental and Clinical Psychopharmacology, 23(1), 1–21. doi:10.1037/a0038550

Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., … Charney, D. S. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry, 51(3), 199–214. doi:10.1001/archpsyc.1994.03950030035004

Kuhn, R. (1958). The treatment of depressive states with g 22355 (imipramine hydrochloride). American Journal of Psychiatry, 115(5), 459–464. doi:10.1176/ajp.115.5.459

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., … Duman, R. S. (2010). mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists. Science, 329(5994), 959–964. doi:10.1126/science.1190287

López-Muñoz, F., Alamo, C., Juckel, G., & Assion, H.-J. (2007). Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part I: monoamine oxidase inhibitors. Journal of Clinical Psychopharmacology, 27(6), 555–559. doi:10.1097/jcp.0b013e3181bb617

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 20(24), 9104–9110. doi:10.1523/JNEUROSCI.20-24-09104.2000

Mukherjee, S. (2012, April 19). The Science and History of Treating Depression. The New York Times. Retrieved from

Muller, J. C., Pryor, W. W., Gibbons, J. E., & Orgain, E. S. (1955). DEPRESSION AND ANXIETY OCCURRING DURING RAUWOLFIA THERAPY. Journal of the American Medical Association, 159(9), 836–839. doi:10.1001/jama.1955.02960260006002

Nibuya, M., Morinobu, S., & Duman, R. S. (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 15(11), 7539–7547. doi:10.1523/JNEUROSCI.15-11-07539.1995

Pleasure, H. (1954). Psychiatric and Neurological Side-Effects of Isoniazid and Iproniazid. A.M.A. Archives of Neurology & Psychiatry, 72(3), 313–320. doi:10.1001/archneurpsyc.1954.02330030047004

Prozac. (2005). Chemical & Engineering News, 83(25). Retrieved from

Salomon, R. M., Miller, H. L., Krystal, J. H., Heninger, G. R., & Charney, D. S. (1997). Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry, 41(1), 58–64. doi:10.1016/0006-3223(95)00670-2

Salzer, H. M., & Lurie, M. L. (1953). ANXIETY AND DEPRESSIVE STATES TREATED WITH ISONICOTINYL HYDRAZIDE (ISONIAZID). A.M.A. Archives of Neurology & Psychiatry, 70(3), 317–324. doi:10.1001/archneurpsyc.1953.02320330042005

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., … Hen, R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (New York, N.Y.), 301(5634), 805–809. doi:10.1126/science.1083328

Sapolsky, R. M. (2001). Depression, antidepressants, and the shrinking hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 98(22), 12320–12322. doi:10.1073/pnas.231475998

Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., … Veltman, D. J. (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular Psychiatry, 22(6), 900–909. doi:10.1038/mp.2016.60

Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., … Hibar, D. P. (2016). Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Molecular Psychiatry, 21(6), 806–812. doi:10.1038/mp.2015.69

Selikoff, I. J., Robitzek, E. H., & Ornstein, G. G. (1952). TREATMENT OF PULMONARY TUBERCULOSIS WITH HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID. Journal of the American Medical Association, 150(10), 973–980. doi:10.1001/jama.1952.03680100015006

Shaw, D. M., Camps, F. E., & Eccleston, E. G. (1967). 5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides. The British Journal of Psychiatry, 113(505), 1407–1411. doi:10.1192/bjp.113.505.1407

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996). Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America, 93(9), 3908–3913. doi:10.1073/pnas.93.9.3908

Udenfriend, S., Weissbach, H., & Bogdanski, D. F. (1957). Biochemical Findings Relating to the Action of Serotonin. Annals of the New York Academy of Sciences, 66(3), 602–608. doi:10.1111/j.1749-6632.1957.tb40750.x

Wong, D. T., Perry, K. W., & Bymaster, F. P. (2005). The Discovery of Fluoxetine Hydrochloride (Prozac). Nature Reviews Drug Discovery, 4(9), 764–774. doi:10.1038/nrd1821

Zeller, E. A., Barsky, J., Fouts, J. R., Kirchheimer, W. F., & Van Orden, L. S. (1952). Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymes. Experientia, 8(9), 349–350. doi:10.1007/BF02174413

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