- Published7 Aug 2018
- Reviewed7 Aug 2018
Has a doctor ever tested your reflexes with a light whack of your knee? When that little red hammer taps your knee, your leg pops up almost as if it has a mind of its own. That’s because — in a sense — it does. Your knee has access to its own bit of grey matter far from your head — your spinal cord.
The neurons that run from your skin to your spinal cord independently handle a range of reflexive reactions, protecting us from immediate threats like unseen thumbtacks to still-hot electric burners. To get the pain signal from your skin to your spine for on-the-spot processing, you need this orange blob of nerves — the dorsal root ganglion.
In this image, the nerve bundle stays strictly in its lane. In a normal petri dish it would sprawl in all directions, but here the green stripes corral it with a repulsive protein — EphrinA5. This protein family serves as a traffic light in the body that helps direct neurons as they grow.
Cho, H. et al. Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats. Journal of Neuroscience 15 February 2002, 22 (4) 1238-1247. Retrieved August 7, 2018, from http://www.jneurosci.org/content/22/4/1238.long#sec-16
Marquardt, T. et al. Coexpressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane Domains.Cell 121, (1), 127-139, April 8 2005. Retrieved August 7, 2018 from https://www.cell.com/cell/fulltext/S0092-8674(05)00094-2